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In a high glucose environment, CD36 is upregulated, leading to a shift in the metabolic profile of TECs from FAO to glycolysis

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33 In addition, studies of drug gene interactions, transcriptional genes associated with the risk of MDD are also reported, such as D2 subtype of the dopamine receptor (DRD2) and fatty acid desaturase (FADS), 34 which may serve as promising new targets for therapeutic intervention points